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August 29, 2002
Neurochem files Investigational New Drug application for Alzhemed™ to treat
Alzheimer's Disease. About Alzhemed™
Alzhemed™ is an oral small organic molecule that has been specifically designed to
modify the course of the disease by interfering with the association between
glycosaminoglycans (GAGs) and Aß amyloid protein. Alzhemed™ as part of a
"disease modifying" class of drug candidates, is expected to act at two levels:
to prevent and stop the formation and deposition of amyloid fibrils in the brain and in
binding to soluble Aß, to inhibit the inflammatory response associated with amyloid
build-up in Alzheimer's Disease. Its anti-amyloid effectiveness has been demonstrated in an
aggressive transgenic mouse model of brain amyloid with a significant 61% reduction in
Aß plasma levels and a 30% reduction in Aß brain soluble and insoluble fractions
after only 8 weeks of treatment. About Neurochem
Neurochem is an industry leader in the development of therapeutic drugs and diagnostic tools
for central nervous system (CNS) and amyloid-related diseases associated with aging. The
Company has to date advanced three drug candidates to clinical trials: Fibrillex™, for
the life-threatening orphan disease, secondary amyloidosis in a pivotal Phase II/III clinical
trial, Alzhemed™, for the treatment of Alzheimer's Disease advancing to Phase II clinical
trials, and Cerebril™, for hemorrhagic stroke also advancing to Phase II clinical
trials. The Company has built a strong product pipeline by developing a novel, proprietary
series of compounds that inhibit the formation, deposition and toxic effects of amyloid
fibrils within the body. Neurochem's overall therapeutic programs target CNS disorders
including Alzheimer's disease, epileptic seizures caused by head trauma or acute brain
injury, and hemorrhagic stroke (due to cerebral amyloid angiopathy), and other
life-threatening diseases including systemic amyloidosis and amyloid-associated diabetes
type II. (www.neurochem.com).
All of the statements contained in this news release, other than statements of fact which
are independently verifiable at the date hereof, are forward-looking statements. Such
statements, based as they are on the current expectations of management, inherently involve
numerous risks and uncertainties, known and unknown. Some examples of known risks are: the
impact of general economic conditions, general conditions in the pharmaceutical industry, changes
in the regulatory environment in the jurisdictions in which Neurochem does business, stock
market volatility, fluctuations in costs, and changes to the competitive environment due to
consolidation or otherwise. Consequently, actual future results may differ materially from
the anticipated results expressed in the forward-looking statements.
For further Information, please contact: |
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